Unusual Features of the

SARS

CoV

Genome Suggesting Sophisticated

Lab

oratory

Modifi

cation Rather Than Natural Evolution and

Delineation

robable

ynthetic

oute

Meng Yan (MD, PhD)

, Shu Kang (PhD)

, Shanchang Hu (PhD)

Yan

Research

–

An Independent Research Team

Correspondence: team.lmyan@gmail.com

Abstract

The COVID

19 pandemic caused by the novel coronavirus SARS

CoV

2 has led to over 910,000

deaths worldwide and unprecedented decimation of the global economy.

Despite its tremendous impact,

the origin of SARS

CoV

2 has remained mysterious and controversial. The natural origin theory, although

widely accepted, lacks substantial support. The alternative theory that the virus may have come from a

research laborator

y is, however, strictly censored on peer

reviewed scientific journals. Nonetheless,

SARS

CoV

2 shows biological characteristics that are inconsistent with a naturally occurring, zoonotic

virus. In this report, we describe the genomic, structural, medical,

and literature evidence, which, when

considered together, strongly contradicts the natural origin theory. The evidence shows that SARS

CoV

2 should be a laboratory product created by using bat coronaviruses ZC45 and/or ZXC21 as a template

and/or backbone.

Building upon the evidence, we further postulate a synthetic route for SARS

CoV

demonstrating that the laboratory

creation of this coronavirus is convenient and can be accomplished in

approximately six months. Our work emphasizes the need for an indepen

dent investigation into the

relevant research laboratories. It also argues for a critical look into certain recently published data, which,

albeit problematic, was used to support and claim a natural origin of SARS

CoV

2. From a public health

perspective,

these actions are necessary as knowledge of the origin of SARS

CoV

2 and of how the virus

entered the human population are of pivotal importance in the fundamental control of the COVID

pandemic as well as in preventing similar, future pandemics.

Public

ation Note (July 1

, 2021):

The three Yan reports used scientific evidence and analyses to prove that SARS

CoV

2 is an

Unrestricted Bioweapon

created by military scientists of the Chinese Communi

Party (CCP) regime.

These reports have played a pivotal role in revealing the true identity of the ongoing

Unrestricted

Biowarfare

For this reason

, the CCP and its allies have been constantly launch

ing attacks at the Yan

Reports. Very recently, the

Rule of Law Foundation

(ROLF) and

Rule of Law Society

(ROLS), which we

have listed as our honorary affiliation in our reports, requested

Zenodo

to have the original uploads of our

reports closed. This was

done by the ROLF & ROLS without informing us authors or seeking our

agreement. This is

unacceptable

because the work was done by us authors independently with no financial

assistance provided by the ROLF & ROLS or any other organization. Their action here

has no scientific

basis and is against the rules of scientific publications. To restore the availability of our reports to the

world, we have therefore re

uploaded the three Yan reports. Our affiliation has been changed to

Yan

Research

–

An Independent Res

earch Team

The current report was originally published on

September 14

, 2020

. As of July 16

, 2021, the

original

Zenodo

upload of it has been viewed

1,339,786

times and downloaded

797,325

times.

Upon mutual

agreement,

Dr. Jie Guan

opted out of

this pub

lication

and

his contributions

have instead been specified

the acknowledgement