Time: Tue Dec 02 14:15:36 1997
To: Patricia Neill <pnpj@db1.cc.rochester.edu>
From: Paul Andrew Mitchell [address in tool bar]
Subject: Genetic Defects Make People Smell like Rotting Fish
Cc:
Bcc:
References:
You mean, I'm safe?
WHEW!!!
One more question:
Can one obtain an odor-altering order?
/s/ Paul Mitchell
http://supremelaw.com
At 04:12 PM 12/2/97 -0400, you wrote:
>Not to worry. Tis genetic, you see, so either you smell like a rotting fish
>or you don't. Horrible, ain't it? :)
>Patty
>
>
>>Patty,
>>
>>I can't stand it. Please don't make
>>me wait any longer. Pleeeeze!!!
>>
>>I GOTTA KNOW! GOTTA KNOW!!
>>
>>Can it be transmitted via modems? 8-]
>>
>>/s/ Paul Mitchell
>>http://supremelaw.com
>>
>>
>>
>>At 10:24 AM 12/2/97 -0400, you wrote:
>>>When all seems dark and dim, just remember--it could be worse.
>>>
>>>
>>>Genetic Defects Make People Smell like
>>> Rotting Fish
>>>
>>> AP
>>> 02-DEC-97
>>>
>>> NEW YORK (AP) Two competing teams of scientists have
>>>identified genetic defects that cause
>>> "fish-odor syndrome," a distressing disease that makes people
>>>smell like rotting fish.
>>>
>>> People with the uncommon disorder can be ridiculed as
>>>children and grow up to be lonely and
>>> depressed.
>>>
>>> "These people lose jobs, they lose friends, they're often
>>>very isolated," said Dr. Eileen Treacy of
>>> McGill University in Montreal, who led one of the teams that
>>>found the flaws in a single gene.
>>>
>>> Robert L. Smith of the Imperial College School of Medicine in
>>>London, a member of the other group,
>>> told of a woman who divorced her husband because she thought
>>>he was not keeping himself clean.
>>> When she learned he had the disorder, "she was full of
>>>remorse," he said.
>>>
>>> No cure is known for fish-odor syndrome, although avoiding
>>>certain foods and taking antibiotics can
>>> help. The new work might lead to better therapies,
>>>researchers said.
>>>
>>> The British research team, led by Ian R. Phillips of the
>>>University of London, reports its work in the
>>> December issue of the journal Nature Genetics. Treacy's
>>>results were presented last month at a
>>> genetics meeting.
>>>
>>> It's not clear how common fish-odor syndrome is. Smith said
>>>it is mentioned in some ancient
>>> literature and even caught the attention of Shakespeare, who
>>>in "The Tempest" describes a character
>>> with "a very ancient and fish-like smell."
>>>
>>> The newly found defects sabotage production of effective
>>>forms of an enzyme called FMO3. The
>>> liver needs that enzyme to process a smelly protein called
>>>TMA or trimethylamine, which is
>>> produced by bacteria in the gut. When TMA goes unprocessed,
>>>it seeps out in a person's breath and
>>> perspiration, causing the offensive body odor.
>>>
>>> People with the disorder are told to avoid eating fish from
>>>the sea, eggs, liver and other foods that
>>> contain raw materials for making TMA. They can also take
>>>antibiotics, but only intermittently, to
>>> reduce production of the stench.
>>>
>>> Everybody has two copies of the FMO3 gene, one inherited from
>>>each parent. The disorder arises
>>> when both copies are defective.
>>>
>>> It appears shortly after birth. Mothers find an affected baby
>>>"smells a bit odd" and may bathe the
>>> child several times a day in the next few months, Smith said.
>>>The baby's bedroom may have a
>>> "heavy, slightly objectionable smell, particularly around the
>>>curtains and furnishings," he said.
>>>
>>> Later, in school, the child is often ridiculed as "Stinky" or
>>>"Fishy," said Smith, who said children
>>> have been forced to leave schools because of the derision.
>>>
>>> Some affected people reach their teens without finding out
>>>why their peers are avoiding them,
>>> knowing only "there's something wrong about them that they
>>>don't understand," Smith said.
>>>
>>> Many affected people go into jobs where they can work alone.
>>>Some start smoking heavily to try to
>>> disguise the smell, Smith said.
>>>
>>> "It's an awful condition for them to have to live with,
>>>particularly teen-agers and young people
>>> trying to make their lives and careers," Smith said. "They
>>>labor under this disadvantage. It's a dead
>>> weight on them."
>>>
>>> Copyright 1997 & The Associated Press. All rights reserved.
>>>This material may not be published, broadcast, rewritten, or
>>> redistributed.
>>>
>>>
>>> Search the net:
>>>
>>>
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>>>
>>
>>===========================================================================
>>Paul Andrew Mitchell, Sui Juris : Counselor at Law, federal witness 01
>>B.A.: Political Science, UCLA; M.S.: Public Administration, U.C.Irvine 02
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