Time: Tue Dec 02 14:17:59 1997
To: Patricia Neill <pnpj@db1.cc.rochester.edu>
From: Paul Andrew Mitchell [address in tool bar]
Subject: Genetic Defects Make People Smell like Rotting Fish


You have given me a laughing attack.


/s/ Paul Mitchell

You mean, I'm safe?


One more question: 

Can one obtain an odor-altering order?

/s/ Paul Mitchell

At 04:12 PM 12/2/97 -0400, you wrote:
>Not to worry. Tis genetic, you see, so either you smell like a rotting fish
>or you don't. Horrible, ain't it? :)
>>I can't stand it.  Please don't make
>>me wait any longer.  Pleeeeze!!!
>>Can it be transmitted via modems?  8-]
>>/s/ Paul Mitchell
>>At 10:24 AM 12/2/97 -0400, you wrote:
>>>When all seems dark and dim, just remember--it could be worse. 
>>>Genetic Defects Make People Smell like
>>>               Rotting Fish
>>>               AP
>>>               02-DEC-97
>>>               NEW YORK (AP) Two competing teams of scientists have
>>>identified genetic defects that cause
>>>               "fish-odor syndrome," a distressing disease that makes people
>>>smell like rotting fish. 
>>>               People with the uncommon disorder can be ridiculed as
>>>children and grow up to be lonely and
>>>               depressed. 
>>>               "These people lose jobs, they lose friends, they're often
>>>very isolated," said Dr. Eileen Treacy of
>>>               McGill University in Montreal, who led one of the teams that
>>>found the flaws in a single gene. 
>>>               Robert L. Smith of the Imperial College School of Medicine in
>>>London, a member of the other group,
>>>               told of a woman who divorced her husband because she thought
>>>he was not keeping himself clean.
>>>               When she learned he had the disorder, "she was full of
>>>remorse," he said. 
>>>               No cure is known for fish-odor syndrome, although avoiding
>>>certain foods and taking antibiotics can
>>>               help. The new work might lead to better therapies,
>>>researchers said. 
>>>               The British research team, led by Ian R. Phillips of the
>>>University of London, reports its work in the
>>>               December issue of the journal Nature Genetics. Treacy's
>>>results were presented last month at a
>>>               genetics meeting. 
>>>               It's not clear how common fish-odor syndrome is. Smith said
>>>it is mentioned in some ancient
>>>               literature and even caught the attention of Shakespeare, who
>>>in "The Tempest" describes a character
>>>               with "a very ancient and fish-like smell." 
>>>               The newly found defects sabotage production of effective
>>>forms of an enzyme called FMO3. The
>>>               liver needs that enzyme to process a smelly protein called
>>>TMA or trimethylamine, which is
>>>               produced by bacteria in the gut. When TMA goes unprocessed,
>>>it seeps out in a person's breath and
>>>               perspiration, causing the offensive body odor. 
>>>               People with the disorder are told to avoid eating fish from
>>>the sea, eggs, liver and other foods that
>>>               contain raw materials for making TMA. They can also take
>>>antibiotics, but only intermittently, to
>>>               reduce production of the stench. 
>>>               Everybody has two copies of the FMO3 gene, one inherited from
>>>each parent. The disorder arises
>>>               when both copies are defective. 
>>>               It appears shortly after birth. Mothers find an affected baby
>>>"smells a bit odd" and may bathe the
>>>               child several times a day in the next few months, Smith said.
>>>The baby's bedroom may have a
>>>               "heavy, slightly objectionable smell, particularly around the
>>>curtains and furnishings," he said. 
>>>               Later, in school, the child is often ridiculed as "Stinky" or
>>>"Fishy," said Smith, who said children
>>>               have been forced to leave schools because of the derision. 
>>>               Some affected people reach their teens without finding out
>>>why their peers are avoiding them,
>>>               knowing only "there's something wrong about them that they
>>>don't understand," Smith said. 
>>>               Many affected people go into jobs where they can work alone.
>>>Some start smoking heavily to try to
>>>               disguise the smell, Smith said. 
>>>               "It's an awful condition for them to have to live with,
>>>particularly teen-agers and young people
>>>               trying to make their lives and careers," Smith said. "They
>>>labor under this disadvantage. It's a dead
>>>               weight on them." 
>>>                Copyright 1997 & The Associated Press. All rights reserved.
>>>This material may not be published, broadcast, rewritten, or
>>>                                          redistributed. 
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>>Paul Andrew Mitchell, Sui Juris      : Counselor at Law, federal witness 01
>>B.A.: Political Science, UCLA;   M.S.: Public Administration, U.C.Irvine 02
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